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Lowering homocysteine levels by supplementing with B vitamins has been shown to reduce the rate of brain atrophy in elderly people with mild cognitive impairment.[ref] Researchers have found that high homocysteine exacerbates amyloid-beta-induced cell death in the brain.[ref] Osteoporosis: Researchers think the connection between high homocysteine and osteoporosis could be due to dysregulation of the transsulfuration pathway rather than a problem with the remethylation of homocysteine

& Cliff, J

Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression

doi: 10.1016/j.neo.2022.100874

Women with PCOS should discuss the health benefits/risks of supplement use, appropriate dosage, and be monitored by a healthcare professional.

However, it is not known whether this specific enzyme defect was responsible for the patients chronic hemolytic anemia