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doi: 10.1080/21688370.2017.1373208 95 TalebiS.KarimifarM.HeidariZ.MohammadiH.AskariG

[246] showed that Nrf2 inhibition increased oxidative stress and aggravated hypertension in mice, whereas Nrf2 activation alleviated hypertension during Ang II infusion, highlighting its therapeutic relevance.Mitochondrial dysfunction, including impaired energy metabolism, increased mtROS, and mtDNA damage, amplifies ferroptosis and worsens endothelial injury [247, 248]