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In CaOx-exo-treated macrophages, mRNA levels of M1 markers (TNF-, iNOS, CD86) were significantly upregulated, while M2 markers (CD163, IL-10, TGF-1, Arg-1) were downregulated (Fig

However, some conditions can boost the production of free radicals and create oxidative stressa condition in which the body's antioxidant defenses are unable to neutralize the overwhelming quantity of free radicals being produced

Wang, Y., Guo, Y., Hu, Y., Sun, Y

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Targeting cell cycle and apoptosis pathways p53/mouse double minute 2 homolog (MDM2)/ARF and p16/cyclinD-CDK4/6/Rb signaling pathways regulate cell cycle and cell proliferation

It constantly scans for harmful molecules, known as free radicals that damage cells, speed up aging, and contribute to disease