Studies reveal a vicious cycle between this pathway and oxidative stress
J Immunol 161:25242532 Liu SX, Hou FF, Guo ZJ, Nagai R, Zhang WR, Liu ZQ, Zhou ZM, Zhou M, Xie D, Wang GB, Zhang X (2006) Advanced oxidation protein products accelerate atherosclerosis through promoting oxidative stress and inflammation
Applications in Research: Studies into metabolic regulation and weight management models Appetite suppression and satiety pathway investigations Research on energy balance and glucose homeostasis Exploration of synergistic effects between incretin mimetics and amylin analogs Storage & Handling: Store lyophilized peptide at -20C, protected from light and moisture
Cancer 89 , 13751382 (2003)
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Abbreviations AMPK: AMP-activated protein kinase AP-1: Activator protein-1 ARE: Antioxidant response element ATP: Adenosine triphosphate CAD: Coronary artery disease cAMP: Cyclic adenosine monophosphate CAT: Catalase Co Q10: Coenzyme Q10 CVD: Cardiovascular disease DM: Diabetes mellitus eNOS: Endothelial nitric oxide synthase GLUT2: Glucose transporter 2 GPx: Glutathione peroxidase HDL-C: High-density lipoprotein cholesterol HO-1: Heme oxygenase 1 IDF: International Diabetes Federation IRS: Insulin receptor substrate Keap1: Kelch-like ECH-associated protein 1 LDL-C: Low-density lipoprotein cholesterol MDA: Malondialdehyde NADPH: Nicotinamide adenine dinucleotide phosphate NO: Nitric oxide NOX: NADPH oxidases Nrf2: Nuclear factor erythroid 2-related factor 2 PPAR : Peroxisome proliferator-activated receptor alpha QUICKI: Quantitative insulin sensitivity check index ROS: Reactive oxygen species Sirt1: Sirtuin1 SOD: Superoxide dismutase SREBPs: Sterol regulatory element-binding proteins TAC: Total antioxidant capacity TC: Total cholesterol TG: Triglyceride VLDL: Very low-density lipoprotein
