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The cleared media was adjusted to a final concentration of 50 mM sodium/potassium phosphate at pH 6.5 and applied to the cation exchange column (Hitrap SP HP, Cytiva)

Nature 632 , 383389 (2024)

94 Phase 3 cardiovascular outcomes trials with Lp(a) inhibitors are currently ongoing

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Administration methods for contacting macrophages are well known in the art, particularly because macrophages are commonly present in various tissue types (see Ries et al (2014) Cancer Cell 25: 846-859