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Transplacental and perinatal administration followed by oral administration (feed) In a study of chronic toxicity and carcinogenicity, 429 male and 423 female Swiss mice were obtained by mating groups containing an equal number of males and females (three groups of 40 and two groups of 60 mice, with a total of 240 overall, no further details provided)

Nicotine Tob Res 21(8):10451050

5K), further confirming the regulation of CoA levels by xCT activity

Therefore, the ferroptosis fundamental characteristics, that is, GPX4 inactivation, GSH depletion, iron deposition, and lipid peroxidation, have garnered attention in the context of RA pathogenesis