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We aimed to stratify the risk of HCC accurately and refine the current screening strategy

The reducing environment promotes the DNA binding of HIF-1 in the nucleus, which is achieved by TXN-mediated Ref-1 reduction [28, 29]

In conclusion, this study supports the use of glutathione amino acid precursors in skincare formulations

Compared with monotherapy, the combination increased them in the WT-sensitive groups by 2.23-fold and 2.82-fold, whereas decreased those in the KO-resistant groups by 7.53-fold and 11.37-fold, respectively (Table 2 WT-S 1 versus KO-S 2 )

The top 50 metabolites, ranked by peak area, are listed in Supplementary Table 1

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