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Similarly, ROS also enhance inflammation through NF-B pathway activation, leading to IB degradation, NF-B nuclear translocation, and transcriptional upregulation of inflammatory mediators [93, 94]

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That is, if they have generalized hypermobility (criteria I), evidence of a syndrome of musculoskeletal complications of a systemic syndrome or a family history (criteria II), or if they have exclusion of alternate diagnoses (criteria III)

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