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Rebound Hypertension Crisis: Abrupt discontinuation of clonidine can trigger severe rebound hypertension, tachycardia, headache, and agitation within 24 to 36 hours (Cao et al., 2022

Elevated cAMP levels stimulate protein kinase A (PKA), which phosphorylates target proteins and inhibits myosin light chain kinase (MLCK), resulting in relaxation of bronchial smooth muscle and bronchodilation

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