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It was recently returned to the market after being removed several years ago due to severe side effects in a number of dogs

Toxicol Lett 152:159166 Potter WZ, Manji HK, Rudorfer MV (1998) Tricyclics and tetracyclics

Curr Opin Immunol 70:714 Lim SA et al (2022) Lipid metabolism in T cell signaling and function

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Leaf senescence: correlated with increased levels of membrane permeability and lipid peroxidation, and decreased levels of superoxide dismutase and catalase

However, a second line of defense awaits these phages inside the bacterial cell, namely, a diverse repertoire of Type IV REs with GmrS-like effectors