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3.2 HIF Pathway Hypoxia Inducible factors (HIFs) are transcription factors, consisting of an oxygen-labile subunit (HIF-) and a constitutively stable subunit (HIF-), which play pivotal roles in inducing cellular responses to hypoxia and in regulating immune cell effector functions (95, 96)

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Oral B12 supplementation is more accessible and cost-effective but relies on gastric intrinsic factor for absorption, rendering it unsuitable for individuals with gastric disorders or malabsorption syndromes