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Trends Endocrinol Metab (2009) 20:43643

TR forms a heterodimer complex with RXR which binds to a thyroid response element (TRE), stimulating or inhibiting gene transcription

However, in another clinical study involving patients with gradually progressive (slow-spreading) vitiligo (focal, vulgaris, and acrofacial) divided into two groups, group A (receiving G

The high response rate to treatment with IBAT (odevixibat) in these patients suggests that in PFIC4, despite tight junction dysfunction, there is a regular passage of BAs from the hepatocytes to the biliary tree and the bowel, allowing odevixibat to interrupt the enterohepatic circulation and decrease the recirculating BA pool [1, 42, 47]

Deferoxamine exhibited protective effects in some experimental models of brain ischemia in vivo, for instance in ischemia associated with hyperglycemia (Xing et al.2009) or neonatal brain ischemia (Palmer et al.1994)

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