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The funder was responsible for study design, interpretation of data, and the writing of this article

However, Zich argues that most of the perceived benefits people are reporting from B12 injections might just be a placebo effect

The study concluded that B12 deficiency disrupts catecholamine degradation and sympathetic nervous system function, directly contributing to orthostatic intolerance

Thus, insulin resistance leading to elevated portal insulin levels may explain, at least partially, the overlap in individual IGF-I levels between older GH-deficient subjects and GH-sufficient subjects (85, 86)

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Supplementary information Rights and permissions About this article Cite this article Muttenthaler, M., King, G.F., Adams, D.J