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This impairment leads to the accumulation of dysfunctional mitochondria, exacerbating oxidative stress and inflammation [227]

Furthermore, disruption in the CR process leads to the production of higher CTCs, particularly during sleep time, which can further promote the tumor progression as these CTCs display elevated expression of circadian hormone receptors, and hormones such as melatonin modulate their release (174, 175)

NDs are closely related to age, as the onset risk increases and symptom severity worsens with advancing age (Sun et al., 2024)

Imaging techniques (i.e., ERCP) have also shown biliary tract calculi in many patients with established PSC, suggesting the removal of calculi as an exclusionary criterion (Kaw et al, 1995)

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In such cases, B12 injections bypass the gastrointestinal tract, directly increasing vitamin levels and helping alleviate symptoms like fatigue and neurological issues