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Cyclic GMP-dependent protein kinase type I (cGKI) exerts a cytoprotective function, as cGKI-deficient mice exhibit anemia and splenomegaly due to accelerated erythrocyte clearanceunderscoring cGKIs capacity to buffer pro-eryptotic signals ( 2+ activity, and its activator pyrvinium pamoate further influences this process via activating Cl -sensitive Ca 2+ -permeable cation channels and inhibiting Ca 2+ -activated K + channels (Kucherenko et al., 2012

RNA was extracted, and QuantiTect Primer Assay was used to assess gene expression

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The Ct-derived expression values were adjusted by a common scaling factor to ensure that the average of control values equaled 1 or 100

The list identifies carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa , and Enterobacteriaceae , as well as rifampicin-resistant Mycobacterium tuberculosis , as critical threats