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The decreased airway resistance and hyperinflation effects were also confirmed in the HIACE study, 46 suggesting that NAC could significantly improve small airway function

Neurosci Biobehav Rev (2000) 24(6):62738

Nevertheless, the involvement of an hypomethylation cannot be ruled out, because in vitro studies suggest that a low concentration of homocysteine specifically inhibits endothelial cell regeneration and directly activates quiescent vascular smooth muscle cells through a mechanism involving decreased carboxymethylation of p21 ras (Lee and Wang, 1999