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223 However, it was noted that there were several limitations that may have confounded results, including: lack of adequate placebo (olive oil was sometimes used)

Boon R, Goodman JJ, Martinez J, Marks GL, Gamble M, Welch C

A study of this type was difficult to conduct on 21 extracts, and, at the same time, we could not select a limited number of extracts without a broader initial screening

In another trial, 87% of the participants preferred transdermal patches over oral medication, showing the need for transdermal drug delivery systems (TDDS) for GLP-1 drugs

Endocrinology (2004) 145(2):9941002

Pediatrics 1981;67(1):95-100