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Studies have revealed that alterations in the enzymatic activity or expression levels of CYP3A4 are key determinants of drug efficacy and toxicity [48]

Nat Genet 41:11381143

A literature search allowed us to identify two human glutathione reductase ( Hs GR) inhibitors 97,98 with structural data available in PDB, namely xanthene (1XAN) and pyocyanin (3SQP)

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Dimer dissociation can be simply defined as a dimer ( M 2 ) dissociating into monomers ( M ) with conservation of mass, meaning that a single dimer dissociates into two monomers: Despite MS not being quantitative, the detected intensity of each species comprising a complex in equilibrium is dependent upon their relative concentrations in solution

Acknowledgements We thank Elisabeth Rushing (Institute of Neuropathology, University Hospital Zurich) for support with the analysis of histological sections and Friedhelm Bladt and Frank Jhrling (Merck, Darmstadt, Germany) for providing EMD1214063 and for helpful discussions