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3.1 NNMT and obesity Obesity stands as a pathological state characterized by the excessive accumulation of body fat and constitutes a significant contributor to MetS

The study found that many patients were highly symptomatic and experienced significant impairment in quality of life

271,272 Additionally, hyperglycemia-induced oxidative and nitrosative stress activates poly(ADP-ribose) polymerase (PARP), a nuclear enzyme involved in DNA repair

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After 30 min pre-incubation, adipocytes were incubated with or without insulin (0.1 ~ 3 nM) for 5 min and the cells were further incubated with isoproterenol (30 or 300 nM) for 30 min