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El pptido de sealizacin se elimina por escisin en el retculo endoplsmico

doi: 10.1016/j.jhepr.2019.10.008

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Excessive fat accumulation inflames adipose tissue during obesity and favors adipose tissue macrophages (ATM) polarization from an anti-inflammatory to a pro-inflammatory phenotype, leading to further recruitment and infiltration of macrophages and other immune cells