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16 In recent years, multiple studies have analyzed the gut microbiota in stool samples obtained from PDAC patients and non-tumor controls through 16S ribosomal RNA sequencing and metagenomic sequencing, revealing notable differences in gut microbiota composition

Similarly, glutamine, glutamate, and arginine levels were downregulated in melanoma interstitial fluid (108)

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Incidences ranging from 0.5 to 6.9% have been reported in North and South America