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In patients with T2DM who do not have atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss, GLP-1 RAs are generally recommended as a second or third-line option as add-on to metformin therapy

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Taking a second dose compounds the problem by introducing excess peptide without improving NNMT binding efficiency

Combined with progressive resistance training, this creates an environment favorable for building lean tissue

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