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These findings emphasize the critical need for early intervention, personalized treatment strategies, and ongoing research into the disorder's pathophysiology and long-term management (Grande et al., 2016

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In this context, large-scale and cost-effective top-down lithography techniques, such as nanoimprinting, nanostencils, interference lithography, and deep and extreme ultraviolet lithography, have emerged as viable alternative manufacturing strategies 261,262

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