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ChaC1 is downstream of the protein kinase R-like ER kinase (PERK)/eukaryotic initiation factor-2 (eIF2)/activating transcription factor (ATF) 4/ATF3/CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) pathway, serving as a pro-apoptotic and pro-ferroptosis component downstream of UPR

Maternal and infant serum carotenoids are associated with infantile atopic dermatitis development

Meal planning tips: Aim for varied colors across meals, prioritize whole foods, include a source of healthy fat to improve absorption of fat-soluble antioxidants, and limit processed foods high in trans fats

However, several external factors exacerbate oxidative stress, including: Lifestyle factors like tobacco and alcohol use activate inflammatory pathways that result in ROS and RNS production