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Transl Psychiatry 11(1):140 Zweig JA et al (2020) Loss of NRF2 leads to impaired mitochondrial function, decreased synaptic density and exacerbated age-related cognitive deficits

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Low glutathione levels have even been linked to diminished dopamine production in the neurons, which means a possible relationship to dopamine-based neurological diseases like Parkinsons disease

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Emerging evidence suggests that A plaques contribute synergistically to disease progression together with oxidative stress, inflammation and mitochondrial dysfunction, while this is less clear in regards to tau pathology (Roy et al., 2023), since A aggregation has been determined as source of oxidative stress (Karapetyan et al., 2022) and oxidative stress has been shown to increase the aggregation of A (Mandal et al., 2022)

If you want to incorporate BPC 157 into a treatment plan for, say, a muscle tear, you want the amplified local effect, and IM injections are best for that