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While trivalent Mn can bind to transferrin, studies where rat brains were perfused with Mn solutions and experiments measuring Mn cellular uptake have shown that Mn 3+ -transferrin is taken up much more slowly than Mn 2+ species [135, 136], suggesting that TfR1 might not be a critical Mn carrier mediating Mn influx across the BBB

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In contrast, patients treated with doses of alprazolam tablets greater than 4 mg/day had more difficulty tapering to zero dose than those treated with less than 4 mg/day