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Although there is no significant difference in AD, combined with the changes in RD, one possible explanation is that along with the progressive demyelination, the severe decreases in axonal packing density caused by loss of myelin sheaths and axons would leading an increase in extracellular water 35 , resulting in the larger continued increase of RD, and subsequent less significant increase of AD, besides, the relative elevation AD value in lesional fibers may also consistent with Wallerian degeneration 12,36

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