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The peptide does not compete for the hGH receptor, does not induce cell proliferation, and exerts direct effects on adipocyte metabolism without systemic endocrine disruption or IGF-1 elevation

Low levels of the zinc-dependent enzyme alkaline phosphatase (ALP)---included in a comprehensive metabolic panel---may help reveal a functional zinc deficiency

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Compared to placebo, the 120 microg three-times-daily and 360 microg two-times-daily doses of pramlintide resulted in additional weight loss of 3.2 kg and 3.3 kg at 4 months, and 6.1 kg and 7.2 kg at 12 months, respectively

Now, the researchers didnt find any such association in women, and the increased risk was mostly among men who smoked

doi:10.1111/obr.12724