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In contrast to the lack of reactive astrocytes, we did observe an increase in Iba1 immunoreactivity in whole brain lysates assessed by western blotting at 72h post-TBI, an effect which was mitigated by Immunocal pretreatment

This is primarily due to the upregulation of phagocyte NADPH oxidase activity, which is a potent producer of superoxide ions (Vermot et al., 2021)

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