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These results implied a dosage trade-off effect, whereby an excessively high concentration of SL might shift from protection to a potential inhibitory effect on protein homeostasis

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In vitro SIL experiment Cell pellets were mixed with 50 l of TCEP and 140 l of 1% formic acid in methanol (containing 150 g l 1 of Tryptophan-d5 as internal standard)

The autophagy lysosomal pathway and neurodegeneration

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