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Description

This mechanism was confirmed in 1983 by Frankel & Nef

91 showed that PFD delayed OA progression by inhibiting the proliferation and migration of FLSs stimulated by TGF-1, while decreasing the expression Col1a1 , TIMP-1 , and ACTA-2 (-SMA), and IL-6 without affecting TNF- levels, thereby alleviating synovial inflammation and fibrosis, as evidenced by improved OARSI scores in OA models