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However, this strategy may disrupt the anticancer effects of immune cells in the bone marrow microenvironment

In terms of cellular senescence, mTOR may promote activity of senescence-associated secretory phenotype SASP), the activation of SASP has been shown to contribute to the secretion of proinflammatory mediators.7,8 Mitochondrial dysfunction has been shown to be associated with aging and age-related diseases, mTOR inhibition can assist with the clearing of old and dysfunctional mitochondria

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Drug-induced or drug-aggravated psoriasis may induce: Localised plaque psoriasis, often affecting scalp, knees, elbows, buttocks and/or genitals Generalised plaque psoriasis, with scattered plaques on all parts of the body Erythroderma when the entire skin surface is red and scaly