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The authors concluded that the microbial metabolite p-cresol competes for sulfonation enzymes, reducing the capacity for sulfonation of acetaminophen (26)

Microbiome-directed probiotic interventions have shown promise in preclinical and clinical studies, ameliorating UC through multiple mechanisms, including anti-inflammatory activity, epithelial barrier restoration, and remodeling of the intestinal microbiota

Genes Cells 18, 544553

Despite these promising findings, DSIP remains largely experimental, with formal clinical approval, standardized dosing, and long-term safety data still lacking

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