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In general, microbiota found in the gut-microbiome favor ISS reduction while human metabolic processes favor ISS oxidation to sulfate for its activation to 3-phosphoadenosine 5-phosphate (PAPS) and numerous sulfonation/sulfurylation reactions [[8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]]

PMID: 62 MuQZhangHShiYXueMWangJDingYet al