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The reasons for this are not completely understood, but we do know that glutathione is extremely important for maintaining intracellular health

10.1002/ange.201911477 91 LiuT.ZhuM.ChangX.TangX.YuanP.TianR.et al (2023)

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They used the MAT2A inhibitor AGI-24512 to simulate MR conditions, treating 316 different tumor-derived cell lines, and found that it inhibited the proliferation of most MTAP-deficient cell lines