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J Neurochem 79:959969 Kim HI, Raffler J, Lu W, Lee JJ, Abbey D, Saleheen D, Rabinowitz JD, Bennett MJ, Hand NJ, Brown C, Rader DJ (2017) Fine mapping and functional analysis reveal a role of SLC22A1 in acylcarnitine transport

They aid in the burning and elimination of fat as well as the toning of muscular mass

Collectively the E4 allele and aging may therefore contribute to AD pathogenesis through aging-related lipid bioenergetics as well as cerebrovascular dysfunctions