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225 RadekM.Pacholczyk-SienickaB.JankowskiS.Albrecht.GrodzkaM.DeptaA.et al (2016)

Nat Med 21:677687

3.8.3 Glyphosate Glyphosate is a widely used herbicide acting via inhibition of the enzyme 5-enolpyruvylshikimate-3-phosphate synthase, which blocks the shikimate pathway responsible for synthesizing aromatic amino acids including phenylalanine, tyrosine and tryptophan (Chiantia et al., 2025)

This dual nature has contributed to theoretical concerns

These therapies must also consider the ability of non-CSCs to dedifferentiate into CSCs under certain conditions, thus repopulating this target population

coli total cell lysates for a long time 14 that could irreversibly covert MG into D-lactate in a single step without the help of any cofactor (Fig