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in addition, quercetin appears to support cardiovascular health by modulating gut microbiome composition

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The major ROS-generating systems in the vascular wall include NADPH oxidase, xanthine oxidase, the mitochondrial electron transport chain, and uncoupled endothelial nitric oxide (NO) synthase ( 5.3.2 Endothelial dysfunction It has been shown that feeding mice a curcumin chow mix (0.1% curcumin + HFD) not only controls body weight gain but also enhances HO-1 enzyme activity in aortic tissues and maintains Sirt1 expression, contributing to the inhibition of oxidative stress in the vasculature and throughout the body (Takano et al., 2018)

Correction of the SAMe deficiency that is characteristic of the AD brain may attenuate or prevent pathological processes driving AD-associated neurodegeneration including aberrant tau hyperphosphorylation and DNA hypomethylation