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Later, another derivative of ketoprofen was reported to improve intracellular brain parenchymal delivery of the parent drug in mice, as investigated by a combinatory mapping approach (124)

However, even with treatment using erythropoiesis-stimulating agents (ESAs) and iron supplements, approximately half of the patients exhibit a hypo-responsive or suboptimal correction of anemia, suggesting the involvement of other significant mechanisms in the development and progression of renal anemia

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doi: 10.1073/pnas.1306285110 Hardy, Margaret C., Daly, Norelle L., Mobli, Mehdi, Morales, Rodrigo A