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These reactions include permanent scarring, skin deformities, cysts, severe infections, etc (1)

Safety data from trials In a paper summarizing 6 randomized, double-blind, placebo-controlled human trials, AOD 9604 did not significantly affect IGF-1 levels, did not impair glucose tolerance, and no serious adverse events (SAEs) were attributed to AOD 9604

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It is unclear to what extent the reduction in lean mass is attributable to loss of skeletal muscle mass per se, which comprises only one component of total body lean mass in mice, but the lack of effect on fat mass is consistent with the reported paucity of IGF-1Rs on mature adipocytes