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Briefly, proteins were digested overnight at 37C using trypsin (Promega, Madison, WI, USA) at 1:20 (enzyme:protein) ratio in 2 M urea/0.1M Tris pH 8.5, 1 mM CaCl 2 reaction buffer

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FBXO22 is responsible for BPC157-induced endothelial cell proliferation and tube formation Having established the functional effects of BPC157, we further investigated its molecular mechanism

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Balb/c mice used in this study were purchased from the Laboratory Animal Center of Shanghai Lingchang Biotechnology

Meier A, Weidmann P, Glck Z, Keusch G, Grimm M, Minder I et al