glutathione deficiency paracetamol Fasting depletes Glutathione, turning "safe" doses into a liver-toxic emergency. Don't let a therapeutic dose become a lethal one. See the safety protocols on BMJ Best Practice via bio. 🔍 #MedEd # Increased resistance to acetaminophen hepatotoxicity

Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S transferase Pi PNAS Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Sex differences in glutathione metabolism and acetaminophen toxicity Paracetamol poisoning PPTX Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione depletion biomarkers ophthalmic acid and 5 oxoproline in humans and rats Integrative Biology (RSC Metabolic pathway for NAPQI formation and detoxification by conjugation Download Scientific Diagram

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