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The RNA-seq analysis results in Fig

Since Asians made up only a fraction of the examined participants, the authors speculate that a more balanced distribution of participants might alter the overall results

Wieters, I

The increased flux of acetyl-CoA will then build up the levels of Krebs intermediates including fumarate and succinate (also inhibitors of prolyl hydroxylase), especially if the biotin-dependent pyruvate carboxylase cannot sustain the production of oxaloacetate, the most limiting substrate of the cycle