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Many patients notice initial sleep benefits including easier sleep onset, fewer nighttime awakenings, or feeling more rested upon waking within the first few nights of therapy due to immediate effects on sleep-regulating systems

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The landmark STEP 1 trial, published in the New England Journal of Medicine in 2021, found that adults using semaglutide 2.4mg weekly alongside lifestyle support lost an average of 14.9% of body weight over 68 weeks, compared to 2.4% in the placebo group