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It was shown that gating is produced due to persulfidation of a cysteine close to the narrow channel after treatment with H 2 S/HS , probably preceded by a transient sulfenic acid intermediate ( Many cases have been reported in which the persulfidation of cysteines in active sites of enzymes disrupted atomic distances and hydrogen bonding tailored for catalysis

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That can be really problematic, especially since my understanding is that it can be cumulative over time

Patra et al., 2019

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Neurological Symptoms Deficient serum folate concentrations can lead to neurological symptoms