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Although relatively small in scale, First-in-Human trials generate several key insights that guide later clinical development.

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Together with the osmotic pressure created by cilia-tethered mucins and the apical epithelial membrane (about 180 Pa), this pressure steadily draws water from the underlying epithelial cells into the airway lining fluid, supporting the replacement of water lost through evaporation as the airways humidify inhaled air 1

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