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Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity

Properties: Chicoric Acid, Taraxasterol, Chlorogenic Acid

RRID: AB_881738

The study protocol was approved by the medical ethics committee of the Maastricht University Medical Center+, the Netherlands and was in line with the Helsinki Declaration of Human Rights (identifier: NL73600.068.20/METC 20033)

Thus, ANKIB1 preferentially generates K11-Ub chains and its catalytic activity facilitates TLR3-induced TBK1 activation, suggesting that ANKIB1-generated K11-Ub may be crucial for TBK1 recruitment and activation upon TLR3 stimulation

For quantitative western blots, anti-rabbit immunoglobulin G (IgG) (H + L) (Dylight 800 conjugates) and anti-mouse IgG (H + L) (Dylight 680 conjugates) (Cell signaling) were used as secondary antibodies