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For example, IL-12 encapsulated in pH-sensitive polymers composed of modified PEG-poly(L-lysine) was designed to be released specifically in the acidic environment of the tumor microenvironment ( Figure 4 ) (91)

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Biol Psychiatry 57:12151220 Bilder RM, Volavka J, Lachman HM, Grace AA (2004) The catechol- O -methyltransferase polymorphism: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes

Data analysed by one-way ANOVA, multiple comparison, Bonferroni post hoc test ( e , f , k and l ) and two-way repeated measures ANOVA to assess main effects of treatment ( b , d , h - j , n and p )