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The privately held company first filed for approval of the drug in September 1999 but the New Drug Application was rejected by the FDA in 2002

A phase II clinical study of combining FOLFIRI and bevacizumab plus erlotinib in 2nd-line chemotherapy for patients with metastatic colorectal cancer

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The labelled dataset was used as the training input for a random-forest classifier 18 , which used the magnitude of incidence and prevalence, along with the rates of change, to inform the model and define the three epidemiologic stages (Extended Data Fig

The peptide may offer greatest value as an adjunctive therapy combined with conventional hair loss treatments or as a maintenance therapy following more aggressive interventions

For each tested threshold, the OR represented the association between elevated B12 and solid cancers by comparing patients with B12 concentration above this threshold with those having B12 concentration below this threshold