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To view or add a comment, sign in Disease biology matters: our latest study compares two closely related CD28-costimulated anti-CD19 CAR T-cell products across autoimmune diseases and aggressive B-cell lymphoma

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Since the mVCN of the cell product that was infused into these two patients was 1.9 and 2.1, the relatively low mVCN determined 24 months later in the peripheral blood of these two patients indicate that the modified cells may have failed to properly engraft, survive and/or produce -globin (and in consequence hemoglobin), and were therefore unable to meaningfully contribute to hematopoiesis and support correction of the disease

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